chromosomal study of couples with the history of recurrent spontaneous abortions with diagnosed blightded ovum

نویسندگان

sahar shekoohi department of medical genetics, school of medicine, mashhad university of medical sciences, mashhad, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences)

majid mojarrad department of medical genetics, school of medicine, mashhad university of medical sciences, mashhad, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences)

reza raoofian department of medical genetics, school of medicine, mashhad university of medical sciences, mashhad, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences)

shahab ahmadzadeh department of medical genetics, school of medicine, mashhad university of medical sciences, mashhad, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences)

چکیده

spontaneous abortion (sab) is the most common complication of early pregnancy. numerous risk factors are associated with an increased risk of pregnancy loss such as: blighted ovum. the aim of this study was to determine the frequency of balanced chromosomal translocations in couples with a history of recurrent spontaneous abortions and ultrasound diagnosed blighted ovum. sixty eight couples with the history of spontaneous abortion (diagnosed blighted ovum) were selected and introduced into this survey during 2007-2012 at medical genetics department of mashhad university of medical sciences. giemsa banding technique was used to search for chromosomal balanced translocations. demographic assessment has not shown any age difference between blighted ovum suffering couples and general population. consanguineous marriages in blighted ovum suffering couples was significantly higher (p value < 0.001) than non-consanguineous marriages (68.5% versus 31.5%), while in general population 62% of were non-consanguineous. the incidences of balanced chromosomal rearrangements as well as the rate of chromosome 9 inversion were 8.3 percent each, in non-consanguineous blighted ovum suffering couples and the remaining (83.4%) showed normal karyotypes. there was no chromosome 9 inversion in consanguineous blighted ovum suffering couples and the incidence of balanced chromosomal rearrangements was 2.3%. with regard to relatively low incidence of balanced chromosomal rearrangements in consanguineous couples with blighted ovum, it would be reasonable to suggest that single gene determinants may play an important role in such pregnancy complications rather than chromosomal disorders.

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منابع مشابه

Chromosomal Study of Couples with the History of Recurrent Spontaneous Abortions with Diagnosed Blightded Ovum

Spontaneous abortion (SAb) is the most common complication of early pregnancy. Numerous risk factors are associated with an increased risk of pregnancy loss such as: Blighted ovum. The aim of this study was to determine the frequency of balanced chromosomal translocations in couples with a history of recurrent spontaneous abortions and ultrasound diagnosed blighted ovum. Sixty Eight couples wit...

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Chromosomal Study of Couples with the History of Recurrent Spontaneous Abortions with Diagnosed Blightded Ovum

Spontaneous abortion (SAb) is the most common complication of early pregnancy. Numerous risk factors are associated with an increased risk of pregnancy loss such as: Blighted ovum. The aim of this study was to determine the frequency of balanced chromosomal translocations in couples with a history of recurrent spontaneous abortions and ultrasound diagnosed blighted ovum. Sixty Eight couples wit...

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Chromosomal Analysis of Couples with Repeated Spontaneous Abortions in Northeastern Iran

Background Cytogenetic study of reproductive wastage is an important aspect in determining the genetic background of early embryogenesis. Approximately 15 to 20% of all pregnancies in humans are terminated as recurrent spontaneous abortions (RSAs). The aim of this study was to detect chromosome abnormalities in couples with RSAs and to compare our results with those reported previously. Materia...

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Chromosomal abnormalities in couples with recurrent first trimester abortions.

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Balanced Chromosomal Rearrangement in Recurrent Spontaneous Abortions: A Case Report

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Chromosomal analysis is an important etiological investigation in couples with repeated spontaneous abortions as it helps in genetic counseling and deciding about further reproductive options. Abortions ,specially first trimester abortions is a very common complication and a matter of concern for couples planning pregnancy. Balanced chromosomal rearrangements in either parent is an important ca...

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عنوان ژورنال:
international journal of molecular and cellular medicine

جلد ۲، شماره ۴، صفحات ۱۶۴-۱۶۸

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